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KMID : 0359320100500030187
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Korean Journal of Veterinary Research
2010 Volume.50 No. 3 p.187 ~ p.195
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Biological activities and single oral dose toxicity in rat of fermented Rhus verniciflua extract
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Choi Myung-Jin
Lee Seung-Jin
Jang Seung-Hee
Reza Ahsanur
Hong Joo-Heon
Jung Hee-Kyoung
Park Seung-Chun
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Abstract
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In this study, we investigated the biological activities such as anti-tumor, anti-oxidant and antiinflammatory activities as well as single oral dose toxicity of fermented Rhus verniciflua extract (FRVE). In order to examine anti-tumor activity of FRVE, the sarcoma 180 cells were treated with FRVE at various concentrations (0.03, 0.3, 3 and 30 mg/mL) in microtetrazolium (MTT) assay. In MTT assay, all the cells treated with FRVE at various concentrations have shown a significant difference compared with control (p < 0.05). In xanthine oxidase inhibition assay to examine the antioxidant activity, the xanthine oxidase inhibition rate of FRVE at 1.5 mg/mL and 15 mg/mL was 85 ± 15.01% and 99 ± 16.02%, respectively. Nitric oxide production in RAW 264.7 cells showed that FRVE showed a significant anti-inflammation effect at 3 mg/mL (p < 0.05). In single oral dose toxicity study, no differences were observed between control and treated groups in clinical signs, body weight gains, feed and water consumptions. The results indicated that lethal dose 50 (LD50) of FRVE was found to be higher than 5,000 mg/kg in this experiment. From the above results, we may suggest that FRVE might have useful as a material for functional food and/ or animal pharmaceutics.
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KEYWORD
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anti-inflammation, anti-oxidant, anti-tumor, Rhus verniciflua, single-dose toxicity
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